Neutrino astronomy is the branch of astronomy that observes astronomical objects with neutrino detectors in special observatories. Neutrinos are created as a result of certain types of radioactive decay, nuclear reactions such as those that take place in the Sun or high energy astrophysical phenomena, in nuclear reactors, or when cosmic rays hit atoms in the atmosphere. Neutrinos rarely interact with matter, meaning that it is unlikely for them to scatter along their trajectory, unlike photons. Therefore, neutrinos offer a unique opportunity to observe processes that are inaccessible to optical telescopes, such as reactions in the Sun's core. Neutrinos can also offer a very strong pointing direction compared to charged particle cosmic rays.

Since neutrinos interact weakly, neutrino detectors must have large target masses (often thousands of tons). The detectors also must use shielding and effective software to remove background signal.